Title : Effects of the novel antipsychotic agent 7-(4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro -2(1H)-quinolinone (OPC-14597) on prolactin release from the rat anterior pituitary gland.

Pub. Date : 1996 Apr

PMID : 8613910






3 Functional Relationships(s)
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1 In in vitro experiments on the isolated anterior pituitary, the spontaneous PRL release was decreased by talipexole, a dopamine D2 receptor full agonist, in a dose-dependent manner to 36% of the basal release, and the decrease was antagonized by haloperidol, a D2 receptor antagonist. Haloperidol prolactin Rattus norvegicus
2 The decrease in PRL release induced by OPC-14597 was completely antagonized by haloperidol. Haloperidol prolactin Rattus norvegicus
3 In in vivo experiments, haloperidol increased the serum PRL levels to 8 times the basal PRL level, whereas talipexole decreased the levels to 49% of the basal level. Haloperidol prolactin Rattus norvegicus