Title : Mechanisms of interleukin-1beta regulation of nitric oxide synthase in cardiac myocytes.

Pub. Date : 1996 Mar

PMID : 8613229






1 Functional Relationships(s)
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1 Thus, our data suggest that (1) interleukin-1beta is the primary cytokine in myocyte iNOS regulation and acts predominantly at the transcriptional level; (2) interleukin stimulation of iNOS mRNA and protein is coupled to a tyrosine kinase-mediated signaling pathway; and (3) protein kinase C and cAMP can modify interleukin signaling by decreasing and increasing iNOS, respectively. Cyclic AMP interleukin 1 beta Mus musculus