Pub. Date : 1996 Apr 15
PMID : 8605330
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hematopoietic progenitors and interleukin-3-dependent cell lines synthesize histamine in response to calcium ionophore. | Histamine | interleukin 3 | Mus musculus |
| 2 | The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter characteristics, and rhodamine retention, similar to interleukin (IL) 3-induced histamine-producing cells. | Histamine | interleukin 3 | Mus musculus |
| 3 | The finding that all IL-3-dependent cell lines tested so far exhibit increased histamine production and HDC mRNA expression in response to calcium influx lends further support to this notion. | Histamine | interleukin 3 | Mus musculus |
| 4 | It might, therefore, be suggested that the pathway transducing the signal for increased histamine synthesis after IL-3 receptor binding in normal hematopoietic progenitors is modified in these cell lines. | Histamine | interleukin 3 | Mus musculus |