Pub. Date : 1996 Apr
PMID : 8603522
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Retinoic acid modulates the in vivo and in vitro growth of IL-6 autocrine human myeloma cell lines via induction of apoptosis. | Tretinoin | interleukin 6 | Homo sapiens |
| 2 | RA-mediated interruption of the IL-6 autocrine loop was associated with a decrease of bcl-2 oncoprotein expression and apoptosis of the myeloma cells which was RA concentration- and time-dependent. | Tretinoin | interleukin 6 | Homo sapiens |
| 3 | RA-mediated interruption of the IL-6 autocrine loop was associated with a decrease of bcl-2 oncoprotein expression and apoptosis of the myeloma cells which was RA concentration- and time-dependent. | Tretinoin | interleukin 6 | Homo sapiens |
| 4 | Our study indicate that long-term RA treatment interferes in vivo and in vitro with IL-6 autocrine growth of myeloma cell lines, leading to apoptosis. | Tretinoin | interleukin 6 | Homo sapiens |