Pub. Date : 1996 Apr 1
PMID : 8601814
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 2 | Recently, we reported selective alterations in rat spinal calcitonin gene-related peptide (CGRP) markers in morphine-tolerant animals. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 3 | Recently, we reported selective alterations in rat spinal calcitonin gene-related peptide (CGRP) markers in morphine-tolerant animals. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 4 | In fact, increases in CGRP-like immunostaining and decrements in specific [125]hCGRP binding in the superficial laminae of the dorsal horn were correlated with the development of tolerance to the spinal antinociceptive action of morphine. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 5 | Thus, the major goal of the present study was to investigate whether the development of tolerance to spinally infused morphine could be modulated by the blockade of dorsal horn CGRP receptors using the potent CGRP antagonist hCGRP(8-37). | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 6 | Moreover, alterations in spinal CGRP markers seen in morphine-tolerant animals were not observed after a coadministration of morphine and hCGRP(8-37). | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 7 | These results demonstrate the existence of specific interaction between CGRP and the development of tolerance to the spinal antinociceptive effects of morphine. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |
| 8 | They also suggest that CGRP receptor antagonists could become useful adjuncts in the treatment of pain and tolerance to the antinociceptive effects of morphine. | Morphine | calcitonin-related polypeptide alpha | Rattus norvegicus |