Title : Concentrations and effects of oral midazolam are greatly reduced in patients treated with carbamazepine or phenytoin.

Pub. Date : 1996 Mar

PMID : 8598183






1 Functional Relationships(s)
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1 Induction of CYP3A (cytochrome P-450IIIA) enzymes by CBZ and PHT is the most likely explanation of the great difference in the pharmacokinetic and pharmacodynamic profiles of oral midazolam in the two groups. Carbamazepine cytochrome P450 family 3 subfamily A member 4 Homo sapiens