Title : Effect of heparin anticoagulation on neutrophil adhesion molecules and release of IL8: C3 is not essential.

Pub. Date : 1995 Nov

PMID : 8595612






3 Functional Relationships(s)
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1 DESIGN: In a series of experiments, we examined the effect of heparin (4 U/ml) comparing it with ethylenediamine tetra-acetate (EDTA, 1.5 mg/ml) and citrate mixture (100 microliters/ml), heparin dose-response, IL8 (human recombinant IL8) dose-response and protamine (80 micrograms/ml) neutralisation of heparin (4 U/ml) using donor blood (total of 38). Heparin C-X-C motif chemokine ligand 8 Homo sapiens
2 DESIGN: In a series of experiments, we examined the effect of heparin (4 U/ml) comparing it with ethylenediamine tetra-acetate (EDTA, 1.5 mg/ml) and citrate mixture (100 microliters/ml), heparin dose-response, IL8 (human recombinant IL8) dose-response and protamine (80 micrograms/ml) neutralisation of heparin (4 U/ml) using donor blood (total of 38). Heparin C-X-C motif chemokine ligand 8 Homo sapiens
3 Up-regulation of CD11b, down-regulation of L-s and release of IL8 were inversely related to heparin concentration (r = 0.87, P < 0.05). Heparin C-X-C motif chemokine ligand 8 Homo sapiens