Pub. Date : 1995 Nov
PMID : 8591723
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Multiple forms of cytochrome P450 are involved in the metabolism of ondansetron in humans. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | The data in this study collectively indicate that multiple cytochrome P450 forms, including CYP1A1, CYP1A2, CYP2D6, and the CYP3A subfamily, are probably involved in the clearance of ondansetron in humans, with no single form of cytochrome P450 dominating the overall metabolism of ondansetron. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | The data in this study collectively indicate that multiple cytochrome P450 forms, including CYP1A1, CYP1A2, CYP2D6, and the CYP3A subfamily, are probably involved in the clearance of ondansetron in humans, with no single form of cytochrome P450 dominating the overall metabolism of ondansetron. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | The data in this study collectively indicate that multiple cytochrome P450 forms, including CYP1A1, CYP1A2, CYP2D6, and the CYP3A subfamily, are probably involved in the clearance of ondansetron in humans, with no single form of cytochrome P450 dominating the overall metabolism of ondansetron. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | It is therefore concluded that ondansetron is metabolized by multiple forms of cytochrome P450, and this limits the likelihood of a clinically relevant interaction with ondansetron by a modulator of a single form of cytochrome P450. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 6 | It is therefore concluded that ondansetron is metabolized by multiple forms of cytochrome P450, and this limits the likelihood of a clinically relevant interaction with ondansetron by a modulator of a single form of cytochrome P450. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 7 | It is therefore concluded that ondansetron is metabolized by multiple forms of cytochrome P450, and this limits the likelihood of a clinically relevant interaction with ondansetron by a modulator of a single form of cytochrome P450. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 8 | It is therefore concluded that ondansetron is metabolized by multiple forms of cytochrome P450, and this limits the likelihood of a clinically relevant interaction with ondansetron by a modulator of a single form of cytochrome P450. | Ondansetron | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |