Title : S 17162 is a novel selective inhibitor of big ET-1 responses in the rat.

Pub. Date : 1995

PMID : 8587469






3 Functional Relationships(s)
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1 In both models, phosphoramidon selectively inhibited the pressor responses to big ET-1 without influencing those to ET-1, angiotensins (AT-I and AT-II) or norepinephrine. phosphoramidon endothelin 1 Rattus norvegicus
2 It selectively inhibited the pressor responses to big ET-1 with ID50 values of 160 micrograms/kg/min (phosphoramidon: 120 micrograms/kg/min) in the spinal rat and 6 microM (phosphoramidon: 5 microM) in the perfused rat kidney. phosphoramidon endothelin 1 Rattus norvegicus
3 It selectively inhibited the pressor responses to big ET-1 with ID50 values of 160 micrograms/kg/min (phosphoramidon: 120 micrograms/kg/min) in the spinal rat and 6 microM (phosphoramidon: 5 microM) in the perfused rat kidney. phosphoramidon endothelin 1 Rattus norvegicus