Title : Effect of cytochrome P450 induction on the metabolism and toxicity of ochratoxin A.

Pub. Date : 1996 Feb 9

PMID : 8573185






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using urinary excretion of the enzymes alkaline phosphatase and gamma-glutamyl transferase as an index of renal damage, we observed that pretreatment of rats with PB, which induced hepatic P450 (P450II2B1), protected against OTA nephrotoxicity, whereas cobalt-protoporphyrin IX pretreatment, which decreased P450 levels, exacerbated OTA nephrotoxicity. Phenobarbital gamma-glutamyltransferase 1 Rattus norvegicus