Title : Phosphorylation of recombinant human phenylalanine hydroxylase: effect on catalytic activity, substrate activation and protection against non-specific cleavage of the fusion protein by restriction protease.

Pub. Date : 1996 Jan 15

PMID : 8573072






3 Functional Relationships(s)
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1 The rate of phosphorylation of human phenylalanine hydroxylase was inhibited about 40% by the cofactor tetrahydrobiopterin, and this inhibition was completely prevented by the simultaneous presence of L-phenylalanine (i.e. at turnover conditions). Phenylalanine phenylalanine hydroxylase Homo sapiens
2 Pre-incubation with L-Phe increased the specific activity of phenylalanine hydroxylase 2- to 4-fold, L-Phe acting with positive cooperativity. Phenylalanine phenylalanine hydroxylase Homo sapiens
3 Pre-incubation with L-Phe increased the specific activity of phenylalanine hydroxylase 2- to 4-fold, L-Phe acting with positive cooperativity. Phenylalanine phenylalanine hydroxylase Homo sapiens