Title : p-Hydroxyphenylacetaldehyde is the major product of L-tyrosine oxidation by activated human phagocytes. A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase.

Pub. Date : 1996 Jan 26

PMID : 8567631






3 Functional Relationships(s)
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1 A chloride-dependent mechanism for the conversion of free amino acids into reactive aldehydes by myeloperoxidase. Chlorides myeloperoxidase Homo sapiens
2 We now report that activated neutrophils utilize the myeloperoxidase-H2O2-chloride system to convert L-tyrosine to p-hydroxyphenylacetaldehyde. Chlorides myeloperoxidase Homo sapiens
3 Collectively, these results indicate that activated phagocytes, under physiological conditions, utilize myeloperoxidase to execute the chloride-dependent conversion of L-tyrosine to the lipid-soluble aldehyde, p-hydroxyphenylacetaldehyde, in near quantitative yield. Chlorides myeloperoxidase Homo sapiens