Pub. Date : 1996 Feb 1
PMID : 8564971
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Association between cisplatin resistance and mutation of p53 gene and reduced bax expression in ovarian carcinoma cell systems. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | Following exposure to ionizing radiation or cisplatin, accumulation of the p53 protein was markedly enhanced only in the sensitive cells. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | Taken together, these observations support a role for mutations of the p53 gene in the development of cisplatin resistance in ovarian cancer as a consequence of loss of the ability of p53 to transactivate bax, an apoptosis-inducing gene. | Cisplatin | tumor protein p53 | Homo sapiens |
| 4 | Taken together, these observations support a role for mutations of the p53 gene in the development of cisplatin resistance in ovarian cancer as a consequence of loss of the ability of p53 to transactivate bax, an apoptosis-inducing gene. | Cisplatin | tumor protein p53 | Homo sapiens |