Pub. Date : 1996 Feb 1
PMID : 8562935
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ALDH1 transduction into peripheral blood human hematopoietic progenitor cells also led to significant increases (4- to 10-fold; IC50, approximately 3 to 4 mumol/L) in cyclophosphamide resistance in an in vitro colony-forming assay. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | These findings indicate that ALDH1 overexpression is sufficient to induce cyclophosphamide resistance in vitro and provide a basis for testing the efficacy of ALDH1 gene transduction to protect bone marrow cells from high-dose cyclophosphamide in vivo. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | These findings indicate that ALDH1 overexpression is sufficient to induce cyclophosphamide resistance in vitro and provide a basis for testing the efficacy of ALDH1 gene transduction to protect bone marrow cells from high-dose cyclophosphamide in vivo. | Cyclophosphamide | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |