Title : Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism.

Pub. Date : 1996 Jan 12

PMID : 8557627






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Interleukin-1 enhances pancreatic islet arachidonic acid 12-lipoxygenase product generation by increasing substrate availability through a nitric oxide-dependent mechanism. Nitric Oxide interleukin 1 alpha Homo sapiens
2 IL-1 increases islet expression of nitric oxide (NO) synthase, and the resultant overproduction of NO participates in inhibition of insulin secretion because NO synthase inhibitors, e.g. NG-monomethyl-arginine (NMMA), prevent this inhibition. Nitric Oxide interleukin 1 alpha Homo sapiens