Title : Cisplatin and taxol activate different signal pathways regulating cellular injury-induced expression of GADD153.

Pub. Date : 1996 Jan

PMID : 8554977






1 Functional Relationships(s)
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1 We conclude that (1) taxol and cDDP activate GADD153 promoter activity through different mechanisms; (2) the signal transduction pathway mediating induction by cDDP involves a tyrosine kinase inhibitable by tyrphostin B46; and (3) that inhibition of this signal transduction pathway by tyrphostin synergistically enhances cDDP toxicity. Tyrphostins DNA damage inducible transcript 3 Homo sapiens