Pub. Date : 1995 Nov
PMID : 8554738
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Sodium ions attenuate the inhibitory effects of neuropeptide Y on norepinephrine release in rat hypothalamus. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 2 | In an in vitro study, NPY significantly inhibited the stimulation-evoked norepinephrine release from hypothalamic slices in a dose-dependent manner. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 3 | The blockade of alpha 2-adrenergic receptors by RX 781094 diminished the inhibitory effects of NPY on norepinephrine release. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 4 | Pretreatment of slices with pertussis toxin (a potent inhibitor of the Gi-proteins) significantly attenuated the suppressive effects of NPY and UK 14,304 on norepinephrine release. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 5 | When the sodium concentration of the perfusion medium was increased, the inhibitory effects of NPY and UK 14,304 on norepinephrine release were significantly reduced. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 6 | These results show that NPY might inhibit norepinephrine release that is partially mediated by alpha 2-adrenergic receptors and the pertussis toxin-sensitive Gi-proteins in rat hypothalamus. | Norepinephrine | neuropeptide Y | Rattus norvegicus |
| 7 | Moreover, less suppressive effects of NPY and UK 14,304 on norepinephrine release in the presence of excess sodium ions suggest that sodium ions might actively participate in regulating the NPY and alpha 2-adrenergic receptor mediated functions in the central nervous system. | Norepinephrine | neuropeptide Y | Rattus norvegicus |