Title : CGRP antagonists enhance gastric acid secretion in 2-h pylorus-ligated rats.

Pub. Date : 1995

PMID : 8545247






2 Functional Relationships(s)
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1 CGRP antibody (4.8 mg/kg, IV) increased by 93% gastric acid secretion in conscious rats with pylorus ligation for 2 h. (CGRP(8-73) (128 nmol/kg, IV) also enhanced the acid response measured 2 h after pylorus ligation in conscious rats and in urethane-anesthetized rats infused with pentagastrin by 91% and 56%, respectively. Pentagastrin calcitonin-related polypeptide alpha Rattus norvegicus
2 CGRP antibody (4.8 mg/kg, IV) increased by 93% gastric acid secretion in conscious rats with pylorus ligation for 2 h. (CGRP(8-73) (128 nmol/kg, IV) also enhanced the acid response measured 2 h after pylorus ligation in conscious rats and in urethane-anesthetized rats infused with pentagastrin by 91% and 56%, respectively. Pentagastrin calcitonin-related polypeptide alpha Rattus norvegicus