Title : Thymidine kinase deficient cells with decreased TTP pools are hypersensitive to DNA alkylating agents.

Pub. Date : 1996 Jan 2

PMID : 8538643






2 Functional Relationships(s)
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1 When treated with N-methyl-N"-nitronitrosoguanidine or ethyl methanesulfonate, HL-60 TK deficient cells showed significantly increased killing and mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus relative than did wild-type. Ethyl Methanesulfonate hypoxanthine phosphoribosyltransferase 1 Homo sapiens
2 When treated with N-methyl-N"-nitronitrosoguanidine or ethyl methanesulfonate, HL-60 TK deficient cells showed significantly increased killing and mutation frequencies at the hypoxanthine-guanine phosphoribosyl transferase (HGPRT) locus relative than did wild-type. Ethyl Methanesulfonate hypoxanthine phosphoribosyltransferase 1 Homo sapiens