Title : Effect of fucoidan during activation of human plasminogen.

Pub. Date : 1995 Aug 1

PMID : 8533120






4 Functional Relationships(s)
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1 During t-PA activation of Glu-Plg, a high degree of synergism was observed between 6-AH and fucoidan while the enhancement by CNBr-Fbg was not influenced by fucoidan and was reversed by 6-AH. Aminocaproic Acid plasminogen activator, tissue type Homo sapiens
2 During t-PA activation of Glu-Plg, a high degree of synergism was observed between 6-AH and fucoidan while the enhancement by CNBr-Fbg was not influenced by fucoidan and was reversed by 6-AH. Aminocaproic Acid plasminogen activator, tissue type Homo sapiens
3 The results are interpreted to suggest that CNBr-Fbg and 6-AH compete with each other for the same lysine binding sites (LBS) on the Plg molecule while fucoidan acted synergistically with 6-AH in enhancing the t-PA activation of Glu-Plg by a different mechanism. Aminocaproic Acid plasminogen activator, tissue type Homo sapiens
4 The results are interpreted to suggest that CNBr-Fbg and 6-AH compete with each other for the same lysine binding sites (LBS) on the Plg molecule while fucoidan acted synergistically with 6-AH in enhancing the t-PA activation of Glu-Plg by a different mechanism. Aminocaproic Acid plasminogen activator, tissue type Homo sapiens