Pub. Date : 1995 Dec
PMID : 8531073
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline on human CYP3A catalyzed 1"-hydroxy midazolam formation in vitro. | 1-hydroxymethylmidazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | The ability of fluoxetine, norfluoxetine, sertraline and desmethyl sertraline to inhibit the CYP3A subfamily of cytochromes P450 was examined in vitro, using the formation of 1"-hydroxy midazolam as a probe for CYP3A catalytic activity. | 1-hydroxymethylmidazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | The best fit model of the inhibition of CYP3A-mediated 1"-hydroxy midazolam formation by all four compounds examined was determined to be mixed inhibition. | 1-hydroxymethylmidazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |