Title : Influence of exogenous ras and p53 on P-glycoprotein function in immortalized rodent fibroblasts.

Pub. Date : 1995

PMID : 8527864






3 Functional Relationships(s)
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1 The ras genes, in addition to activation of exogenous human mdr1 gene promoter, caused an increase in (i) expression of endogenous mdr1 mRNA, (ii) Pgp activity as determined by flow cytometry analysis of Rhodamine 123 exclusion, and (iii) resistance of cells to the cytotoxic action of colchicine and some other drugs. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
2 The ras genes, in addition to activation of exogenous human mdr1 gene promoter, caused an increase in (i) expression of endogenous mdr1 mRNA, (ii) Pgp activity as determined by flow cytometry analysis of Rhodamine 123 exclusion, and (iii) resistance of cells to the cytotoxic action of colchicine and some other drugs. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens
3 The ras genes, in addition to activation of exogenous human mdr1 gene promoter, caused an increase in (i) expression of endogenous mdr1 mRNA, (ii) Pgp activity as determined by flow cytometry analysis of Rhodamine 123 exclusion, and (iii) resistance of cells to the cytotoxic action of colchicine and some other drugs. Colchicine ATP binding cassette subfamily B member 1 Homo sapiens