Title : The response of human gingival fibroblasts to interleukin-1 in their metabolic conversion of two androgenic substrates.

Pub. Date : 1995 Oct

PMID : 8526810






4 Functional Relationships(s)
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1 The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied. Androstenedione interleukin 1 alpha Homo sapiens
2 The effects of interleukin-1 (IL-1) on the metabolism of two androgenic substrates, testosterone and 4-androstenedione, that can be converted to the potent anabolic metabolite 5 alpha-dihydrotestosterone (DHT) were studied. Androstenedione interleukin 1 alpha Homo sapiens
3 There was a 1.8-fold increase in DHT synthesis (n = 7; p < 0.02) and a 1.9-fold increase in 4-androstenedione in response to IL-1 (n = 7; p < 0.02) (Wilcoxon signed-rank test for non-parametric, paired observations). Androstenedione interleukin 1 alpha Homo sapiens
4 Both testosterone and 4-androstenedione were effective substrates in forming the potent metabolite DHT in significant amounts in response to IL-1. Androstenedione interleukin 1 alpha Homo sapiens