Title : Effects of 3 aminoglycoside antibiotics (kanamycin, gentamicin and fradiomycin) on the thrombin-induced aggregation and intracellular Ca2+ mobilization of human platelets.

Pub. Date : 1993 Mar

PMID : 8510321






2 Functional Relationships(s)
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1 This study was aimed at determining whether the thrombin (TRB)-induced aggregation and intracellular free Ca2+ ([Ca(2+)]i) mobilization of fura-2-loaded human platelets would be affected by aminoglycoside antibiotics (AGs), i.e., kanamycin (KM), gentamicin (GM) and fradiomycin (FRM) with 4, 5 and 6 amino groups in their molecules, respectively. Fura-2 coagulation factor II, thrombin Homo sapiens
2 This study was aimed at determining whether the thrombin (TRB)-induced aggregation and intracellular free Ca2+ ([Ca(2+)]i) mobilization of fura-2-loaded human platelets would be affected by aminoglycoside antibiotics (AGs), i.e., kanamycin (KM), gentamicin (GM) and fradiomycin (FRM) with 4, 5 and 6 amino groups in their molecules, respectively. Fura-2 coagulation factor II, thrombin Homo sapiens