Title : Insulin-like growth factor-I regulates transcription of the elastin gene.

Pub. Date : 1993 Jun 15

PMID : 8509381






1 Functional Relationships(s)
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1 The addition of IGF-I (50 ng/ml) to quiescent smooth muscle cell cultures resulted in a 5-fold increase in the steady-state levels of tropoelastin mRNA beginning between 2 and 4 h and reaching maximal levels at 8 h. Addition of cycloheximide blocked the effect of IGF-I. Cycloheximide insulin-like growth factor 1 Rattus norvegicus