Pub. Date : 1993 Jun
PMID : 8504748
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF alpha caused a significant and dose-dependent inhibition of 8-Br-cAMP-stimulated testosterone secretion by 35.9 +/- 9.9%, 90.9 +/- 1.7%, and 96.9 +/- 1.4% with 0.1, 1.0, and 10.0 ng/ml TNF alpha, respectively. | 8-Bromo Cyclic Adenosine Monophosphate | tumor necrosis factor | Mus musculus |
| 2 | TNF alpha caused a significant and dose-dependent inhibition of 8-Br-cAMP-stimulated testosterone secretion by 35.9 +/- 9.9%, 90.9 +/- 1.7%, and 96.9 +/- 1.4% with 0.1, 1.0, and 10.0 ng/ml TNF alpha, respectively. | 8-Bromo Cyclic Adenosine Monophosphate | tumor necrosis factor | Mus musculus |
| 3 | Treatment with 0.1, 1.0, and 10.0 ng/ml TNF alpha decreased 8-Br-cAMP-stimulated P450scc mRNA by 11.5 +/- 6.9%, 29.3 +/- 2.7%, and 59.2 +/- 8.7%, and decreased 8-Br-cAMP-induced P450c17 mRNA 41.9 +/- 13.5%, 95.7 +/- 2.3%, and 98.5 +/- 1.2%, respectively. | 8-Bromo Cyclic Adenosine Monophosphate | tumor necrosis factor | Mus musculus |
| 4 | Within 48 h after the removal of TNF alpha from culture, P450c17 mRNA was restored to 80.6 +/- 3.1% of the level in cultures treated with 8-Br-cAMP alone for 4 days. | 8-Bromo Cyclic Adenosine Monophosphate | tumor necrosis factor | Mus musculus |
| 5 | These data demonstrate that TNF alpha inhibits both basal and 8-Br-cAMP-stimulated testosterone secretion from Leydig cells in a dose-dependent manner. | 8-Bromo Cyclic Adenosine Monophosphate | tumor necrosis factor | Mus musculus |