Title : Variation in human thymidylate synthase is associated with resistance to 5-fluoro-2'-deoxyuridine.

Pub. Date : 1993 May

PMID : 8502227






1 Functional Relationships(s)
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1 Two human colorectal tumor cell lines are differentially sensitive to growth inhibition by 5-fluorodeoxyuridine (FdUrd); cell line RCA is less sensitive to FdUrd than is cell line C. Thymidylate synthase (TS), a target of FdUrd, has been purified to homogeneity from both cell lines. Floxuridine thymidylate synthetase Homo sapiens