Title : Inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). 2. Modification of fatty acid anilide ACAT inhibitors: bioisosteric replacement of the amide bond.

Pub. Date : 1993 May 28

PMID : 8496932






1 Functional Relationships(s)
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Protein Name
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1 Only replacement of amide bonds with isosterases having both hydrogen bond donor and acceptor functionalities yielded compounds retaining ACAT inhibitory activity. Hydrogen carboxylesterase 1 Homo sapiens