Pub. Date : 1993 Jan-Feb
PMID : 8490103
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |
| 2 | In the present study, the role of protein kinase C (PKC) in the production of TNF alpha was investigated in human peripheral blood monocytes stimulated with either LPS or zymosan. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |
| 3 | The results indicate that inhibition of PKC diminished LPS- or zymosan- induced TNF alpha production in a concentration-dependent manner. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |
| 4 | LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |
| 5 | LPS and zymosan also induced an increase in membrane associated PKC activity in human monocytes, which could be inhibited by pretreatment of the cells with calphostin C. Finally, western blot analysis with PKC isoform-specific antibodies demonstrates that the alpha and xi are the predominent isoforms expressed in human monocytes. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |
| 6 | These data strongly suggest that an initial step in TNF alpha production by human monocytes challenged with physiological stimulants, such as LPS and zymosan, involves a PKC-dependent mechanism. | Zymosan | proline rich transmembrane protein 2 | Homo sapiens |