Title : Decreased cholesterol biosynthesis in fibroblasts from patients with Parkinson disease.

Pub. Date : 1993 Apr

PMID : 8484956






1 Functional Relationships(s)
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1 14C-Acetate incorporation into cholesterol of these fibroblasts was 27.8 +/- 9.4% that observed in normal fibroblasts, and the reduced cholesterol synthesis was confirmed by measuring the activity of the rate-limiting enzyme HMGCoA reductase which averaged 6.64 +/- 2.50 nmol/h/mg protein in the patient"s fibroblasts compared to 14.70 +/- 0.69 nmol/h/mg protein in the control fibroblasts. 14c-acetate 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens