Pub. Date : 1993 Mar
PMID : 8479597
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats. | malic acid | malate dehydrogenase 2, NAD (mitochondrial) | Mus musculus |
| 2 | Since the malate-aspartate shuttle in brain has been shown to be closely linked to brain energy metabolism and neurotransmitter synthesis, the activity of MDH, one of the enzymes of the malate-aspartate shuttle, was studied in cortical non-synaptic mitochondria (mMDH) and cytosol (cMDH) in 1-4 day, 18-20 day and 7-8 week old rats. | malic acid | malate dehydrogenase 2, NAD (mitochondrial) | Mus musculus |
| 3 | This study also determined if endogenous compounds, previously shown to alter malate metabolism, affected MDH activities. | malic acid | malate dehydrogenase 2, NAD (mitochondrial) | Mus musculus |
| 4 | The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle. | malic acid | malate dehydrogenase 2, NAD (mitochondrial) | Mus musculus |