Title : Prostaglandin E2 downregulates Kupffer cell production of IL-1 and IL-6 during hepatic regeneration.

Pub. Date : 1993 Apr

PMID : 8476047






2 Functional Relationships(s)
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1 This enhancement of regenerating liver KC to produce IL-1 and IL-6 was increased (P < 0.05) by placing these same KC in 10 microM arginine RPMI 1640 culture media. Arginine interleukin 6 Homo sapiens
2 When the cyclooxygenase inhibitor indomethacin (10 microM) was added to cultures, the production of PGE2 by KC was prevented, and in arginine-depleted cultures, IL-1 and IL-6 production was upregulated (P < 0.05). Arginine interleukin 6 Homo sapiens