Title : Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15.

Pub. Date : 1993 Apr 15

PMID : 8475101






3 Functional Relationships(s)
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1 The vertebrate CDC2/cyclin B1 complex is an essential regulator of the onset of mitosis and is inhibited by phosphorylation of CDC2 on Thr-14 and Tyr-15. Threonine cyclin dependent kinase 1 Homo sapiens
2 The vertebrate CDC2/cyclin B1 complex is an essential regulator of the onset of mitosis and is inhibited by phosphorylation of CDC2 on Thr-14 and Tyr-15. Threonine cyclin dependent kinase 1 Homo sapiens
3 Furthermore, our data suggest that the phosphorylation and dephosphorylation of CDKs on Thr-14 and Tyr-15 may regulate not only the G2/M transition but also other transitions in the cell cycle and that individual cdc25 family members may regulate distinct cell cycle checkpoints. Threonine cyclin dependent kinase 1 Homo sapiens