Title : Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

Pub. Date : 1993 Apr

PMID : 8474022






1 Functional Relationships(s)
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1 The prototypic CYP1A xenobiotic inhibitor and substrate probes alpha-naphthoflavone, ellipticine, 7-ethoxycoumarin and 7-ethoxyresorufin all inhibited CYP1A1- and CYP1A2-mediated phenacetin O-deethylation as well as the high-affinity component of human liver phenacetin O-deethylase activity. ethoxyresorufin cytochrome P450 family 1 subfamily A member 1 Homo sapiens