Title : Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages.

Pub. Date : 1993 May 1

PMID : 8473748






3 Functional Relationships(s)
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1 Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid. Nitrogen Dioxide tumor necrosis factor Mus musculus
2 Therefore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways. Nitrogen Dioxide tumor necrosis factor Mus musculus
3 Therefore, picolinic acid may affect NO2- production via both TNF-alpha-dependent and TNF-alpha-independent pathways. Nitrogen Dioxide tumor necrosis factor Mus musculus