Title : Picolinic acid, a catabolite of L-tryptophan, is a costimulus for the induction of reactive nitrogen intermediate production in murine macrophages.

Pub. Date : 1993 May 1

PMID : 8473748






5 Functional Relationships(s)
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1 ANA-1 macrophages did not produce nitrite (NO2-) constitutively, but accumulated detectable levels of NO2- on exposure to IFN-gamma. Nitrogen Dioxide interferon gamma Mus musculus
2 Picolinic acid, although ineffective by itself, augmented IFN-gamma-induced NO2- production. Nitrogen Dioxide interferon gamma Mus musculus
3 Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid. Nitrogen Dioxide interferon gamma Mus musculus
4 Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid. Nitrogen Dioxide interferon gamma Mus musculus
5 Neutralizing concentrations of anti-TNF mAb completely abrogated IFN-gamma- and IFN-gamma plus rTNF-alpha-induced NO2- production in ANA-1 macrophages, but only decreased by approximately 50% the synergistic interaction between IFN-gamma and picolinic acid. Nitrogen Dioxide interferon gamma Mus musculus