Pub. Date : 1993 Mar 23
PMID : 8467877
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cyclosporine A induces endothelin-1 release from cultured rat vascular smooth muscle cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 2 | Since vascular smooth muscle cells in culture are capable of secreting endothelin-1 (ET-1), we investigated the effect of cyclosporine A on ET-1 release from rat vascular smooth muscle cells. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 3 | Cyclosporine A 10 microM significantly (P < 0.05) enhanced the secretion of ET-1 at 2, 8, 24 and 48 h (6.5 +/- 0.5, 11 +/- 0.7, 19 +/- 0.5, 37 +/- 1.6 fmol/10(6) cells, respectively) compared with vehicle (4.7 +/- 0.3, 8.1 +/- 0.6, 15 +/- 0.4, 27 +/- 2.0 fmol/10(6) cells, respectively). | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 4 | The cyclosporine-induced synthesis of ET-1 by vascular smooth muscle cell may participate in the pathogenesis of cyclosporine-induced vasoconstriction and vasculopathy via an autocrine regulatory mechanism. | Cyclosporine | endothelin 1 | Rattus norvegicus |
| 5 | The cyclosporine-induced synthesis of ET-1 by vascular smooth muscle cell may participate in the pathogenesis of cyclosporine-induced vasoconstriction and vasculopathy via an autocrine regulatory mechanism. | Cyclosporine | endothelin 1 | Rattus norvegicus |