Pub. Date : 1993 Mar
PMID : 8467355
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 2 | Other selective 5-HT1A receptor ligands (0.3-30 mg kg-1, s.c.) either mimicked the 8-OH-DPAT response (ipsapirone, at 10 and 30 mg kg-1, s.c.) or were inactive (buspirone and gepirone). | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |
| 3 | We conclude that 8-OH-DPAT produces an antidepressant-like effect in the Porsolt test which is mediated via postsynaptic 5-HT1A receptors. | 8-Hydroxy-2-(di-n-propylamino)tetralin | 5-hydroxytryptamine (serotonin) receptor 1A | Mus musculus |