Title : Sex hormones and dexamethasone modulate interleukin-5 gene expression in T lymphocytes.

Pub. Date : 1993 Mar

PMID : 8461254






4 Functional Relationships(s)
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Protein Name
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1 Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4. Tetradecanoylphorbol Acetate interleukin 5 Mus musculus
2 Progesterone and testosterone were as effective as PMA in inducing IL-5 mRNA levels in the T cell hybrid NIMP-TH1 and induced IL-5, -3 and -2 mRNA accumulation in the T cell lymphoma EL-4. Tetradecanoylphorbol Acetate interleukin 5 Mus musculus
3 The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s). Tetradecanoylphorbol Acetate interleukin 5 Mus musculus
4 The presence of the protein synthesis inhibitor cycloheximide completely prevented PMA-induced synthesis of IL-5 mRNA by both NIMP-TH1 and EL-4 cells, indicating that induction of IL-5 mRNA via PMA stimulation requires de novo synthesis of a presumptive trans-acting factor(s). Tetradecanoylphorbol Acetate interleukin 5 Mus musculus