Pub. Date : 1993 Mar 15
PMID : 8457195
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Addition of taurocholic acid, the most predominant bile acid in rat bile, to the culture medium suppressed cholesterol 7 alpha-hydroxylase activity and mRNA time- and dose-dependently. | Taurocholic Acid | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 2 | Maximal suppression of cholesterol 7 alpha-hydroxylase mRNA (-91%) and enzyme activity (-89%) was observed after a 16 h incubation period with 50 microM taurocholic acid. | Taurocholic Acid | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 3 | Mass production of bile acids (chenodeoxycholic acid and beta-muricholic acid) was inhibited to a similar extent as the cholesterol 7 alpha-hydroxylase when different concentrations of taurocholic acid were used, giving maximal inhibition (-81%) at 50 microM taurocholic acid. | Taurocholic Acid | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 4 | Mass production of bile acids (chenodeoxycholic acid and beta-muricholic acid) was inhibited to a similar extent as the cholesterol 7 alpha-hydroxylase when different concentrations of taurocholic acid were used, giving maximal inhibition (-81%) at 50 microM taurocholic acid. | Taurocholic Acid | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |
| 5 | Glycocholic acid and unconjugated cholic acid were equally effective as taurocholic acid in suppressing cholesterol 7 alpha-hydroxylase mRNA. | Taurocholic Acid | cytochrome P450 family 7 subfamily A member 1 | Rattus norvegicus |