Title : Suppression of oncogene-induced transformation by a deletion mutant of c-jun.

Pub. Date : 1993 Apr

PMID : 8455942






2 Functional Relationships(s)
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1 In addition, transformation of rat embryo cells induced by an activated ras gene in the presence of the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) or by ras plus SV40 large T antigen is also inhibited by this dominant-negative mutant, suggesting that a member of the jun or fos family is involved in the pathways leading to transformation in these systems as well. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 In addition, transformation of rat embryo cells induced by an activated ras gene in the presence of the tumor promoter 12-O-tetradecanoyl phorbol 13-acetate (TPA) or by ras plus SV40 large T antigen is also inhibited by this dominant-negative mutant, suggesting that a member of the jun or fos family is involved in the pathways leading to transformation in these systems as well. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus