Title : In vivo characterization of a phosphoramidon-sensitive endothelin-converting enzyme in the rat.

Pub. Date : 1993 Feb 16

PMID : 8449237






3 Functional Relationships(s)
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1 Very high doses of big ET-1 (> 20 mg/kg) were capable of over-riding the effect of phosphoramidon and produced characteristic pressor responses suggesting that the inhibition by phosphoramidon can be considered competitive in nature. phosphoramidon endothelin 1 Rattus norvegicus
2 Very high doses of big ET-1 (> 20 mg/kg) were capable of over-riding the effect of phosphoramidon and produced characteristic pressor responses suggesting that the inhibition by phosphoramidon can be considered competitive in nature. phosphoramidon endothelin 1 Rattus norvegicus
3 These results are consistent with the idea that a phosphoramidon-sensitive endothelin-converting enzyme is capable of cleaving both big ET-1 and big ET-3 to the active peptides in the rat. phosphoramidon endothelin 1 Rattus norvegicus