Title : Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide.

Pub. Date : 1993 Feb

PMID : 8448809






3 Functional Relationships(s)
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1 Particular ability of cytochrome P-450 CYP3A to reduce glyceryl trinitrate in rat liver microsomes: subsequent formation of nitric oxide. Nitroglycerin cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
2 In the hepatic 9000 x g supernatant containing both NADPH and cytochrome P-450 and glutathione and glutathione transferase, the cytochrome P-450-dependent reaction accounts for 30-40% of the total denitration activity observed under anaerobic conditions, using 100 microM GTN. Nitroglycerin cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus
3 In the hepatic 9000 x g supernatant containing both NADPH and cytochrome P-450 and glutathione and glutathione transferase, the cytochrome P-450-dependent reaction accounts for 30-40% of the total denitration activity observed under anaerobic conditions, using 100 microM GTN. Nitroglycerin cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus