Title : Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report).

Pub. Date : 1993

PMID : 8445979






2 Functional Relationships(s)
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1 Experiments were conducted on three different human liver samples to identify the cytochrome P450 isozyme which is involved in the biotransformation of the class III antiarrhythmic agent, amiodarone, into its major metabolite, desethylamiodarone (DEA). desethylamiodarone cytochrome P450 family 4 subfamily F member 3 Homo sapiens
2 Experiments were conducted on three different human liver samples to identify the cytochrome P450 isozyme which is involved in the biotransformation of the class III antiarrhythmic agent, amiodarone, into its major metabolite, desethylamiodarone (DEA). desethylamiodarone cytochrome P450 family 4 subfamily F member 3 Homo sapiens