Pub. Date : 1993 Mar
PMID : 8441405
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The kinase activity of human p34cdc2 is negatively regulated by phosphorylation at Thr-14 and Tyr-15. | Threonine | cyclin dependent kinase 1 | Homo sapiens |
| 2 | In addition to being negatively regulated by phosphorylation, the kinase activity of p34cdc2 was positively regulated by the cyclin-dependent phosphorylation of Thr-161. | Threonine | cyclin dependent kinase 1 | Homo sapiens |
| 3 | Mutation of p34cdc2 at Thr-161 resulted in the formation of an enzymatically inactive p34cdc2/cyclin B complex both in vivo and in vitro. | Threonine | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Taken together, these results indicate that inhibition of p34cdc2 kinase activity by phosphorylation of Tyr-15 (within the putative ATP binding domain) or by mutation of Thr-161 involves a mechanism other than inhibition of nucleotide binding. | Threonine | cyclin dependent kinase 1 | Homo sapiens |