Title : 1,25-Dihydroxyvitamin D-3 destabilizes c-myc mRNA in HL-60 leukemic cells.

Pub. Date : 1993 Feb 20

PMID : 8439572






1 Functional Relationships(s)
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1 Cycloheximide reversed the instability induced by 1,25(OH)2D3, prolonging the half-life of c-myc mRNA in both uninduced and 1,25(OH)2D3-induced HL-60 cells to > 60 min, indicating a translational requirement for the destabilization process. Cycloheximide MYC proto-oncogene, bHLH transcription factor Homo sapiens