Title : The Adenovirus E1A gene blocks the differentiation of a thyroid epithelial cell line, however the neoplastic phenotype is achieved only after cooperation with other oncogenes.

Pub. Date : 1993 Feb

PMID : 8426735






1 Functional Relationships(s)
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1 The E1A transfected cells, PC E1A, partially lost the dependency on TSH for growth and completely lost the ability to trap iodide and synthesize thyroglobulin; however they did not acquire the typical markers of the neoplastic phenotype. Iodides branched chain keto acid dehydrogenase E1 subunit alpha Rattus norvegicus