Pub. Date : 1993 Jan 15
PMID : 8424795
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence from human studies in vivo and in vitro strongly suggests that the methylhydroxylation of tolbutamide and the 4-hydroxylation of phenytoin, the major pathways in the elimination of these two drugs, are catalysed by the same cytochrome P-450 isoenzyme(s). | Tolbutamide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Tolbutamide was hydroxylated to varying extents by all expressed cytochrome P-450 isoenzymes, although activity was much lower for the expressed 2C8 protein. | Tolbutamide | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |