Pub. Date : 1993 Jul
PMID : 8408478
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Epidermal growth factor (EGF) stimulates progesterone production by human granulosa--luteal cells in culture. | Progesterone | epidermal growth factor | Homo sapiens |
| 2 | Epidermal growth factor (EGF) stimulates progesterone production by human granulosa--luteal cells in culture. | Progesterone | epidermal growth factor | Homo sapiens |
| 3 | When EGF was initiated on day 4, the medium had significantly higher progesterone concentration than control samples on days 6, 8, 10 and 12 of culture (P < 0.01). | Progesterone | epidermal growth factor | Homo sapiens |
| 4 | When EGF was withheld until day 6 or 8, progesterone concentrations were not significantly higher than control values. | Progesterone | epidermal growth factor | Homo sapiens |
| 5 | When EGF was added on day 4 and discontinued on day 8 or 10, progesterone concentrations were reduced significantly (P < 0.001) compared with the group where EGF was added continuously from day 4 to 10. | Progesterone | epidermal growth factor | Homo sapiens |
| 6 | These data suggest that: (i) human granulosa--luteal cells require the early exposure and continuous presence of EGF for the stimulatory effect on progesterone secretion, (ii) cells not exposed initially to EGF do not respond in a similar way, (iii) EGF is capable of maintaining progesterone production for a period > 12 days. | Progesterone | epidermal growth factor | Homo sapiens |