Title : Interferon-gamma inhibition of human thyrotropin receptor gene expression.

Pub. Date : 1993 Oct

PMID : 8408457






2 Functional Relationships(s)
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1 To evaluate the role of interferon-gamma (IFN gamma) on human thyroid-specific gene expression, the effect of IFN gamma on TSH- and cAMP-induced TSH receptor gene expression was studied using cultured thyroid cells obtained from normal thyroid glands and those from patients with Graves" disease. Cyclic AMP interferon gamma Homo sapiens
2 These results indicate that IFN gamma suppresses TSH- and cAMP stimulated human TSH receptor gene expression, resulting in a decrease in the number of TSH receptors. Cyclic AMP interferon gamma Homo sapiens